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2-4 Dichloropyrimidine |Cas N0: 3934-20-1 | India | Manufacturer


2,4-Dichloropyrimidine is a significant compound in organic chemistry, notable for its role as a versatile building block in the synthesis of pharmaceuticals, agrochemicals, and other specialty chemicals. In this detailed guide, we will explore its chemical structure, properties, applications, safety considerations, and more.

Chemical Structure and Properties

2,4-Dichloropyrimidine(cas no-3934-20-1), with the chemical formula C4H2Cl2N2, is a chlorinated derivative of the heterocyclic compound pyrimidine. Its structure consists of a pyrimidine ring (a six-membered aromatic ring containing two nitrogen atoms at positions 1 and 3) with chlorine atoms substituted at the 2 and 4 positions. This compound's chemical structure imparts unique properties that make it valuable in organic synthesis.

Physical Properties

At room temperature, 2,4-dichloropyrimidine appears as a white to pale yellow crystalline solid. It has a molecular weight of approximately 148.98 grams per mole. The compound's melting point typically falls within the range of 68-72°C (154-162°F), and its boiling point is approximately 211-212°C (412-414°F) at atmospheric pressure.


2,4-Dichloropyrimidine is sparingly soluble in water but exhibits better solubility in various organic solvents, including polar solvents like acetone, ethanol, and dimethyl sulfoxide (DMSO). Its solubility characteristics contribute to its utility in organic synthesis reactions, where it often serves as a reagent or intermediate.

Chemical Properties

This compound's chemical properties stem from its pyrimidine ring structure and the presence of chlorine substituents. It can undergo various transformations, including nucleophilic substitution reactions, condensation reactions, and cyclization reactions. These reactions enable the synthesis of a wide range of functionalized pyrimidine derivatives.


2,4-Dichloropyrimidine finds widespread application in organic synthesis as a key intermediate for the production of pharmaceuticals, agrochemicals, and other specialty chemicals. It serves as a building block in the synthesis of pyrimidine-based drugs, herbicides, fungicides, and insecticides. Its versatility and functional group compatibility make it a valuable tool for chemists across different industries.
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